Scientists in Britain have developed a novel blood test that
could provide clues to the ageing process and determine how long an
individual may live.
In a recent publication in the
International Journal of Epidemiology, the scientists say they have
discovered key metabolites in the blood, described as chemical
‘fingerprints’ left behind as a result of early molecular changes before
birth or in infancy which not only could provide clues to health later
in life but also pave the way for the development of therapies to treat
age-related conditions.
Funded by the European Commission,
Researchers from the Department of Twin Research at King’s College
London, the research involves “metabolomic profiling,” the study of
metabolites that specific cellular
processes or changes leave behind in
the blood.
Analysing blood samples donated by over 6,000 twins,
they identified 22 metabolites directly linked to chronological age, the
concentrations of the metabolites were higher in older people than in
younger people.
Their finding suggests that levels of this novel
metabolite, which may be determined in the womb and affected by
nutrition during development, could reflect accelerated aging in later
adult life. The scientists say the findings show it is possible that
these markers of aging can be identified with simple blood tests in the
future, which may provide further clues to the aging process and could
pave the way for development of therapies to treat age-related
conditions.
Ana Valdes, lead researcher from King’s, said that
“human aging is a process influenced by genetic, lifestyle and
environmental factors, but genes only explain a part of the story.
“Understanding
the molecular pathways involved in the aging process could ultimately
pave the way for future therapies to treat age-related conditions. As
these 22 metabolites linked to aging are detectable in the blood, we can
now predict actual age from a blood sample pretty accurately and in the
future this can be refined to potentially identify future rapid
biological aging in individuals,” she further said.
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